This was the first drug to work for me in many years. I had tried Effexor, Celexa, Lexapro 20 years ago. I had had such bad side effects that I did not try anything until recently. My depression and anxiety were tolerable but life was rough. My drs suggested a DNA test first, which showed that I had a fast metabolism rate for the previous drugs and was a good fit for Cymbalta.
I started slow and worked my way up to 60 mg, so far. Life feels a bit more manageable and I have a better sense of perspective with my problems. I did not have any serious side effects, - nothing that is not worth the benefits. I am hoping to go to 90 mg and see how better this can get.
I was prescribed Duloxetine for depression and chronic muscle pain. The first day I took it I felt pretty good. Things quickly got bad, and within 4 days I had two hyperventilating panic attacks never ever had that happen before , suicidal thoughts first time ever , and ended up in the ER from being in excruciating pain.
Stopped taking it and it took three days to get out of my system and four or five days to be able to eat normally again. Biggest side effects for me were suicidal thoughts, nausea, lack of appetite, and burning sensations on my skin. When I first started on cymbalta it felt like it was working but when it was upped it took a turn for the worst. I have never been suicidal in my life and since taking cymbalta it has made me have very dark thoughts.
And it has made me feel like a zombie. I had to leave work because I have had crying spells and my boss had to call my mom to come pick me up I went to the dr and she had to write me off work for 4 days.
I have switched to Paxil and I hope that I can start telling a difference before I go back to work. This is the worst I have ever felt in my life. Duloxetine was a complete game changer for me. I take it at night and it does help me sleep. Only side effect is constipation.
Something I can deal with for the benefits it comes with. I have a wonderful experience with duloxetine for my anxiety and panic attacks.
I have taken 60 mg per day for at least 15 years. Tried reducing to 30 mg with the goal of getting off of it and seeing where my anxiety was.
However, started have severe knee pain and was diagnosed with osteoarthritis in all compartments of my left knee. Went back up to 60 mg of duloxetine and my knee pain went away. I originally tried Zoloft and Effexor. Zoloft killed my sex drive and Effexor made my anxiety worse.
My one negative related to duloxetine is I have the side effect of hyperhydrosis excess sweating. I started at 30 mg. I was only on it for 2 weeks. It helped some with anxiety, but caused migraines. It also caused me to feel depressed. I stopped taking it 3 days ago. Yes, there are withdrawels but I can't take the headaches. I have tried almost every anti depressant and anti anxiety drug out there. Effexor, Prozac, zoloft, wellbutrun,celexa,trazadone, clonazapan, respiradol etc.
This drug is a miracle drug for me. At first it caused me to sleep all the time and some constipation but the sleepiness went away after a few weeks. I have GAD and bi polar. I was on it for 7 years and then stopped because I wanted to see if I was better after a traumatic situation had passed. Everything seemed ok, withdrawal wasn't bad except for some anger mood swings but they went away after a month or so but I also blame that on chronic marijuana use which I stopped.
After about 6 months off the drug my anxiety came back, then my OCD and my social phobia. I couldn't really feel happiness anymore. So I decided to go back on. I just went back on and it should kick in within a few weeks. God bless this for giving me a happier life. Now I can be present for my kids. Pain is mostly gone! Am feeling much more mobile and positive compared to how I was two weeks ago. I can feel my anxiety getting better but may need to give it another couple of weeks to see the full effects.
Sleeping much better than before too! Side effects were insomnia, sweating and nausea which have mostly gone. Both medications and alcohol are metabolized—i. The risk rises if you drink alcohol while taking Cymbalta: One drink is more like two. Certain other drugs, including some OTC ones, can also potentially interact with Cymbalta and be hard on your liver.
In very rare instances, taking aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anti-coagulants while on Cymbalta can cause excessive bleeding.
One very rare but serious side effect of Cymbalta and other antidepressants is serotonin syndrome. Overdose can also be a problem. Other milder symptoms include headaches, dry mouth, loss of appetite, and night sweats. One last word of warning: Be sure to let your doctor know if you have a family or personal history of bipolar disorder, because antidepressants may increase your likelihood of becoming manic.
Weight Loss. United States. Type keyword s to search. Today's Top Stories. Orthostatic hypotension, or a drop in blood pressure when standing or getting up from sleeping, has been reported in patients taking duloxetine. The risk may be greater in patients also taking medications for high blood pressure.
Increased heart rate, irregular menstrual cycle, increased frequency of urination or difficulty urinating, increased liver enzymes, teeth grinding, low sodium symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering , angle closure glaucoma symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye , serotonin syndrome symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death , hypertensive crisis severely elevated blood pressure , myocardial infarction heart attack , Stevens-Johnson Syndrome rash , pancreatitis SNRI antidepressants, including duloxetine, may increase the risk of bleeding events.
Combined use of aspirin, nonsteroidal anti-inflammatory drugs e. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding.
Some cases have been life threatening. To date, there are no known problems associated with long term use of duloxetine. It is a safe and effective medication when used as directed.
Duloxetine should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors MAOIs. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Depressed mood and lack of interest in activities may need up to weeks to fully improve. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults age 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their health care provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment. Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists.
This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication.
Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein.
The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness. About Mental Illness Treatments. About Mental Illness Research.
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